Efficacy and outcome of allogeneic transplantation in IgD and nonsecretory myeloma. A report on behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.
Identifieur interne : 000263 ( Main/Exploration ); précédent : 000262; suivant : 000264Efficacy and outcome of allogeneic transplantation in IgD and nonsecretory myeloma. A report on behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.
Auteurs : Curly Morris [Royaume-Uni] ; Simona Iacobelli [Italie] ; Gösta Gahrton [Suède] ; Anja Van Biezen [Pays-Bas] ; Mary Drake [Royaume-Uni] ; Laurent Garderet [France] ; Michael Potter [Royaume-Uni] ; Anton V. Schattenberg [Pays-Bas] ; Jan J. Cornelissen [Pays-Bas] ; Rose-Marie Hamladji [Algérie] ; Massimo Martelli [Italie] ; Eefke Petersen [Pays-Bas] ; Montserrat Rovira [Espagne] ; Giuseppe Bandini [Italie] ; Nicolaus Kroger [Allemagne] ; Theo De Witte [Pays-Bas]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Agonistes myélo-ablatifs (usage thérapeutique), Analyse de survie (MeSH), Conditionnement pour greffe (MeSH), Déplétion lymphocytaire (MeSH), Europe (MeSH), Femelle (MeSH), Humains (MeSH), Immunoglobuline D (sang), Induction de rémission (MeSH), Lymphocytes T (anatomopathologie), Lymphocytes T (immunologie), Maladie du greffon contre l'hôte (anatomopathologie), Maladie du greffon contre l'hôte (immunologie), Maladie du greffon contre l'hôte (mortalité), Myélome multiple (anatomopathologie), Myélome multiple (classification), Myélome multiple (mortalité), Myélome multiple (thérapie), Mâle (MeSH), Pronostic (MeSH), Récidive (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Transplantation de cellules souches hématopoïétiques (MeSH), Transplantation homologue (MeSH), bêta-2-Microglobuline (immunologie), bêta-2-Microglobuline (sang), Études rétrospectives (MeSH).
- MESH :
- anatomopathologie : Lymphocytes T, Maladie du greffon contre l'hôte, Myélome multiple.
- immunologie : Lymphocytes T, Maladie du greffon contre l'hôte, Myélome multiple, bêta-2-Microglobuline.
- mortalité : Maladie du greffon contre l'hôte, Myélome multiple.
- sang : Immunoglobuline D, bêta-2-Microglobuline.
- thérapie : Myélome multiple.
- usage thérapeutique : Agonistes myélo-ablatifs.
- Adulte, Adulte d'âge moyen, Analyse de survie, Conditionnement pour greffe, Déplétion lymphocytaire, Europe, Femelle, Humains, Induction de rémission, Mâle, Pronostic, Récidive, Résultat thérapeutique, Sujet âgé, Transplantation de cellules souches hématopoïétiques, Transplantation homologue, Études rétrospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Europe (MeSH), Female (MeSH), Graft vs Host Disease (immunology), Graft vs Host Disease (mortality), Graft vs Host Disease (pathology), Hematopoietic Stem Cell Transplantation (MeSH), Humans (MeSH), Immunoglobulin D (blood), Lymphocyte Depletion (MeSH), Male (MeSH), Middle Aged (MeSH), Multiple Myeloma (classification), Multiple Myeloma (mortality), Multiple Myeloma (pathology), Multiple Myeloma (therapy), Myeloablative Agonists (therapeutic use), Prognosis (MeSH), Recurrence (MeSH), Remission Induction (MeSH), Retrospective Studies (MeSH), Survival Analysis (MeSH), T-Lymphocytes (immunology), T-Lymphocytes (pathology), Transplantation Conditioning (MeSH), Transplantation, Homologous (MeSH), Treatment Outcome (MeSH), beta 2-Microglobulin (blood), beta 2-Microglobulin (immunology).
- MESH :
- chemical , blood : Immunoglobulin D, beta 2-Microglobulin.
- chemical , immunology : beta 2-Microglobulin.
- chemical , therapeutic use : Myeloablative Agonists.
- geographic : Europe.
- classification : Multiple Myeloma.
- immunology : Graft vs Host Disease, T-Lymphocytes.
- mortality : Graft vs Host Disease, Multiple Myeloma.
- pathology : Graft vs Host Disease, Multiple Myeloma, T-Lymphocytes.
- therapy : Multiple Myeloma.
- Adult, Aged, Female, Hematopoietic Stem Cell Transplantation, Humans, Lymphocyte Depletion, Male, Middle Aged, Prognosis, Recurrence, Remission Induction, Retrospective Studies, Survival Analysis, Transplantation Conditioning, Transplantation, Homologous, Treatment Outcome.
Abstract
We have recently reported on the outcome of autologous transplantation in the rare myelomas (IgD, IgE, IgM, and nonsecretory [NS]) but there is no real information on the outcome of these conditions after allogeneic transplantation. We used the European Group for Blood and Marrow Transplantation myeloma database to compare the outcomes after allogeneic transplantation of 1354 common myelomas (IgG, IgA, and light chain myeloma) with the outcome in 26 IgD myelomas and 52 NS myelomas. There was little difference between common and the IgD and NS myeloma patients with respect to prognostic factors although the IgD group had a higher beta 2 microglobulin at diagnosis, shorter time to transplantation, and more T cell depletion. IgD and NS patients had a significantly greater achievement of complete remission at conditioning but this did not translate into equivalent progression-free survival and overall survival for the IgD patients although the NS outcome was very similar to that of common myeloma. The PFS and OS of IgD, common, and NS myelomas appear similar after allogeneic transplantation, despite a tendency for higher early relapse rate in IgD myeloma. Allogeneic transplantation may, therefore, be an option to investigate in prospective observational studies.
DOI: 10.1016/j.bbmt.2015.02.012
PubMed: 25708221
Affiliations:
- Algérie, Allemagne, Espagne, France, Italie, Pays-Bas, Royaume-Uni, Suède
- Catalogne, Gueldre, Hambourg, Hollande-Méridionale, Latium, Svealand, Utrecht (province), Wilaya d'Alger, Île-de-France
- Alger, Barcelone, Hambourg, Leyde, Nimègue, Paris, Rome, Rotterdam, Stockholm, Utrecht
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Curation: 000549
- to stream PubMed, to step Checkpoint: 000540
- to stream Main, to step Merge: 000263
- to stream Main, to step Curation: 000263
Le document en format XML
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Schattenberg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Medical Center St, Radboud, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, University Medical Center St, Radboud, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Cornelissen, Jan J" sort="Cornelissen, Jan J" uniqKey="Cornelissen J" first="Jan J" last="Cornelissen">Jan J. Cornelissen</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hamladji, Rose Marie" sort="Hamladji, Rose Marie" uniqKey="Hamladji R" first="Rose-Marie" last="Hamladji">Rose-Marie Hamladji</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hematologie, Centre Pierre et marie Curie, Alger, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Service d'Hematologie, Centre Pierre et marie Curie, Alger</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Martelli, Massimo" sort="Martelli, Massimo" uniqKey="Martelli M" first="Massimo" last="Martelli">Massimo Martelli</name><affiliation wicri:level="1"><nlm:affiliation>Sezione di Ematologia, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sezione di Ematologia, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, Eefke" sort="Petersen, Eefke" uniqKey="Petersen E" first="Eefke" last="Petersen">Eefke Petersen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Medical Center, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, University Medical Center, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Rovira, Montserrat" sort="Rovira, Montserrat" uniqKey="Rovira M" first="Montserrat" last="Rovira">Montserrat Rovira</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Hematology, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bandini, Giuseppe" sort="Bandini, Giuseppe" uniqKey="Bandini G" first="Giuseppe" last="Bandini">Giuseppe Bandini</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Hematology, Bologna University S. Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Hematology, Bologna University S. Orsola, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Kroger, Nicolaus" sort="Kroger, Nicolaus" uniqKey="Kroger N" first="Nicolaus" last="Kroger">Nicolaus Kroger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="De Witte, Theo" sort="De Witte, Theo" uniqKey="De Witte T" first="Theo" last="De Witte">Theo De Witte</name><affiliation wicri:level="3"><nlm:affiliation>Tumor Immunology, University Medical Center St, Radboud, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Tumor Immunology, University Medical Center St, Radboud, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25708221</idno><idno type="pmid">25708221</idno><idno type="doi">10.1016/j.bbmt.2015.02.012</idno><idno type="wicri:Area/PubMed/Corpus">000551</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000551</idno><idno type="wicri:Area/PubMed/Curation">000549</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000549</idno><idno type="wicri:Area/PubMed/Checkpoint">000540</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000540</idno><idno type="wicri:Area/Main/Merge">000263</idno><idno type="wicri:Area/Main/Curation">000263</idno><idno type="wicri:Area/Main/Exploration">000263</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy and outcome of allogeneic transplantation in IgD and nonsecretory myeloma. A report on behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.</title><author><name sortKey="Morris, Curly" sort="Morris, Curly" uniqKey="Morris C" first="Curly" last="Morris">Curly Morris</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Research and Cell Biology, Queens University, Belfast, United Kingdom. Electronic address: curlymorris_cliff@yahoo.com.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Research and Cell Biology, Queens University, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Iacobelli, Simona" sort="Iacobelli, Simona" uniqKey="Iacobelli S" first="Simona" last="Iacobelli">Simona Iacobelli</name><affiliation wicri:level="3"><nlm:affiliation>Centro di Biostatistica e Bioinformatica, Università di Roma Tor Vergata, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Biostatistica e Bioinformatica, Università di Roma Tor Vergata, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gahrton, Gosta" sort="Gahrton, Gosta" uniqKey="Gahrton G" first="Gösta" last="Gahrton">Gösta Gahrton</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Karolinska Institutet & Karolinska University Hospital, Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Karolinska Institutet & Karolinska University Hospital, Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Van Biezen, Anja" sort="Van Biezen, Anja" uniqKey="Van Biezen A" first="Anja" last="Van Biezen">Anja Van Biezen</name><affiliation wicri:level="3"><nlm:affiliation>European Group for Blood and Marrow Transplantation Data Office, Leiden University Medical Centre, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>European Group for Blood and Marrow Transplantation Data Office, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Drake, Mary" sort="Drake, Mary" uniqKey="Drake M" first="Mary" last="Drake">Mary Drake</name><affiliation wicri:level="1"><nlm:affiliation>Haematology Department, Belfast City Hospital, Belfast, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematology Department, Belfast City Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Garderet, Laurent" sort="Garderet, Laurent" uniqKey="Garderet L" first="Laurent" last="Garderet">Laurent Garderet</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, Saint Antoine Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Haematology, Saint Antoine Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Potter, Michael" sort="Potter, Michael" uniqKey="Potter M" first="Michael" last="Potter">Michael Potter</name><affiliation wicri:level="1"><nlm:affiliation>Leukaemia Myeloma Units, Royal Marsden Hospital, London Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leukaemia Myeloma Units, Royal Marsden Hospital, London Surrey</wicri:regionArea><wicri:noRegion>London Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Schattenberg, Anton V" sort="Schattenberg, Anton V" uniqKey="Schattenberg A" first="Anton V" last="Schattenberg">Anton V. Schattenberg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Medical Center St, Radboud, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, University Medical Center St, Radboud, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Cornelissen, Jan J" sort="Cornelissen, Jan J" uniqKey="Cornelissen J" first="Jan J" last="Cornelissen">Jan J. Cornelissen</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hamladji, Rose Marie" sort="Hamladji, Rose Marie" uniqKey="Hamladji R" first="Rose-Marie" last="Hamladji">Rose-Marie Hamladji</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hematologie, Centre Pierre et marie Curie, Alger, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Service d'Hematologie, Centre Pierre et marie Curie, Alger</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Martelli, Massimo" sort="Martelli, Massimo" uniqKey="Martelli M" first="Massimo" last="Martelli">Massimo Martelli</name><affiliation wicri:level="1"><nlm:affiliation>Sezione di Ematologia, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sezione di Ematologia, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, Eefke" sort="Petersen, Eefke" uniqKey="Petersen E" first="Eefke" last="Petersen">Eefke Petersen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Medical Center, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, University Medical Center, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Rovira, Montserrat" sort="Rovira, Montserrat" uniqKey="Rovira M" first="Montserrat" last="Rovira">Montserrat Rovira</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Hematology, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bandini, Giuseppe" sort="Bandini, Giuseppe" uniqKey="Bandini G" first="Giuseppe" last="Bandini">Giuseppe Bandini</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Hematology, Bologna University S. Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Hematology, Bologna University S. Orsola, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Kroger, Nicolaus" sort="Kroger, Nicolaus" uniqKey="Kroger N" first="Nicolaus" last="Kroger">Nicolaus Kroger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="De Witte, Theo" sort="De Witte, Theo" uniqKey="De Witte T" first="Theo" last="De Witte">Theo De Witte</name><affiliation wicri:level="3"><nlm:affiliation>Tumor Immunology, University Medical Center St, Radboud, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Tumor Immunology, University Medical Center St, Radboud, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Europe (MeSH)</term><term>Female (MeSH)</term><term>Graft vs Host Disease (immunology)</term><term>Graft vs Host Disease (mortality)</term><term>Graft vs Host Disease (pathology)</term><term>Hematopoietic Stem Cell Transplantation (MeSH)</term><term>Humans (MeSH)</term><term>Immunoglobulin D (blood)</term><term>Lymphocyte Depletion (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multiple Myeloma (classification)</term><term>Multiple Myeloma (mortality)</term><term>Multiple Myeloma (pathology)</term><term>Multiple Myeloma (therapy)</term><term>Myeloablative Agonists (therapeutic use)</term><term>Prognosis (MeSH)</term><term>Recurrence (MeSH)</term><term>Remission Induction (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Survival Analysis (MeSH)</term><term>T-Lymphocytes (immunology)</term><term>T-Lymphocytes (pathology)</term><term>Transplantation Conditioning (MeSH)</term><term>Transplantation, Homologous (MeSH)</term><term>Treatment Outcome (MeSH)</term><term>beta 2-Microglobulin (blood)</term><term>beta 2-Microglobulin (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Agonistes myélo-ablatifs (usage thérapeutique)</term><term>Analyse de survie (MeSH)</term><term>Conditionnement pour greffe (MeSH)</term><term>Déplétion lymphocytaire (MeSH)</term><term>Europe (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Immunoglobuline D (sang)</term><term>Induction de rémission (MeSH)</term><term>Lymphocytes T (anatomopathologie)</term><term>Lymphocytes T (immunologie)</term><term>Maladie du greffon contre l'hôte (anatomopathologie)</term><term>Maladie du greffon contre l'hôte (immunologie)</term><term>Maladie du greffon contre l'hôte (mortalité)</term><term>Myélome multiple (anatomopathologie)</term><term>Myélome multiple (classification)</term><term>Myélome multiple (mortalité)</term><term>Myélome multiple (thérapie)</term><term>Mâle (MeSH)</term><term>Pronostic (MeSH)</term><term>Récidive (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Transplantation de cellules souches hématopoïétiques (MeSH)</term><term>Transplantation homologue (MeSH)</term><term>bêta-2-Microglobuline (immunologie)</term><term>bêta-2-Microglobuline (sang)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin D</term><term>beta 2-Microglobulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>beta 2-Microglobulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Myeloablative Agonists</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes T</term><term>Maladie du greffon contre l'hôte</term><term>Myélome multiple</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T</term><term>Maladie du greffon contre l'hôte</term><term>Myélome multiple</term><term>bêta-2-Microglobuline</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Graft vs Host Disease</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Graft vs Host Disease</term><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Maladie du greffon contre l'hôte</term><term>Myélome multiple</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Graft vs Host Disease</term><term>Multiple Myeloma</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline D</term><term>bêta-2-Microglobuline</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Myélome multiple</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agonistes myélo-ablatifs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation</term><term>Humans</term><term>Lymphocyte Depletion</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Recurrence</term><term>Remission Induction</term><term>Retrospective Studies</term><term>Survival Analysis</term><term>Transplantation Conditioning</term><term>Transplantation, Homologous</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Conditionnement pour greffe</term><term>Déplétion lymphocytaire</term><term>Europe</term><term>Femelle</term><term>Humains</term><term>Induction de rémission</term><term>Mâle</term><term>Pronostic</term><term>Récidive</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Transplantation homologue</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have recently reported on the outcome of autologous transplantation in the rare myelomas (IgD, IgE, IgM, and nonsecretory [NS]) but there is no real information on the outcome of these conditions after allogeneic transplantation. We used the European Group for Blood and Marrow Transplantation myeloma database to compare the outcomes after allogeneic transplantation of 1354 common myelomas (IgG, IgA, and light chain myeloma) with the outcome in 26 IgD myelomas and 52 NS myelomas. There was little difference between common and the IgD and NS myeloma patients with respect to prognostic factors although the IgD group had a higher beta 2 microglobulin at diagnosis, shorter time to transplantation, and more T cell depletion. IgD and NS patients had a significantly greater achievement of complete remission at conditioning but this did not translate into equivalent progression-free survival and overall survival for the IgD patients although the NS outcome was very similar to that of common myeloma. The PFS and OS of IgD, common, and NS myelomas appear similar after allogeneic transplantation, despite a tendency for higher early relapse rate in IgD myeloma. Allogeneic transplantation may, therefore, be an option to investigate in prospective observational studies. </div></front></TEI><affiliations><list><country><li>Algérie</li><li>Allemagne</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Catalogne</li><li>Gueldre</li><li>Hambourg</li><li>Hollande-Méridionale</li><li>Latium</li><li>Svealand</li><li>Utrecht (province)</li><li>Wilaya d'Alger</li><li>Île-de-France</li></region><settlement><li>Alger</li><li>Barcelone</li><li>Hambourg</li><li>Leyde</li><li>Nimègue</li><li>Paris</li><li>Rome</li><li>Rotterdam</li><li>Stockholm</li><li>Utrecht</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Morris, Curly" sort="Morris, Curly" uniqKey="Morris C" first="Curly" last="Morris">Curly Morris</name></noRegion><name sortKey="Drake, Mary" sort="Drake, Mary" uniqKey="Drake M" first="Mary" last="Drake">Mary Drake</name><name sortKey="Potter, Michael" sort="Potter, Michael" uniqKey="Potter M" first="Michael" last="Potter">Michael Potter</name></country><country name="Italie"><region name="Latium"><name sortKey="Iacobelli, Simona" sort="Iacobelli, Simona" uniqKey="Iacobelli S" first="Simona" last="Iacobelli">Simona Iacobelli</name></region><name sortKey="Bandini, Giuseppe" sort="Bandini, Giuseppe" uniqKey="Bandini G" first="Giuseppe" last="Bandini">Giuseppe Bandini</name><name sortKey="Martelli, Massimo" sort="Martelli, Massimo" uniqKey="Martelli M" first="Massimo" last="Martelli">Massimo Martelli</name></country><country name="Suède"><region name="Svealand"><name sortKey="Gahrton, Gosta" sort="Gahrton, Gosta" uniqKey="Gahrton G" first="Gösta" last="Gahrton">Gösta Gahrton</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Biezen, Anja" sort="Van Biezen, Anja" uniqKey="Van Biezen A" first="Anja" last="Van Biezen">Anja Van Biezen</name></region><name sortKey="Cornelissen, Jan J" sort="Cornelissen, Jan J" uniqKey="Cornelissen J" first="Jan J" last="Cornelissen">Jan J. Cornelissen</name><name sortKey="De Witte, Theo" sort="De Witte, Theo" uniqKey="De Witte T" first="Theo" last="De Witte">Theo De Witte</name><name sortKey="Petersen, Eefke" sort="Petersen, Eefke" uniqKey="Petersen E" first="Eefke" last="Petersen">Eefke Petersen</name><name sortKey="Schattenberg, Anton V" sort="Schattenberg, Anton V" uniqKey="Schattenberg A" first="Anton V" last="Schattenberg">Anton V. Schattenberg</name></country><country name="France"><region name="Île-de-France"><name sortKey="Garderet, Laurent" sort="Garderet, Laurent" uniqKey="Garderet L" first="Laurent" last="Garderet">Laurent Garderet</name></region></country><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Hamladji, Rose Marie" sort="Hamladji, Rose Marie" uniqKey="Hamladji R" first="Rose-Marie" last="Hamladji">Rose-Marie Hamladji</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Rovira, Montserrat" sort="Rovira, Montserrat" uniqKey="Rovira M" first="Montserrat" last="Rovira">Montserrat Rovira</name></region></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Kroger, Nicolaus" sort="Kroger, Nicolaus" uniqKey="Kroger N" first="Nicolaus" last="Kroger">Nicolaus Kroger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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